Treatment of dissociative identity disorder: leveraging neurobiology to optimize success.

INTRODUCTION: Dissociative identity disorder (DID) is a treatable mental health condition that is associated with a range of psychobiological manifestations. However, historical controversy, modern day misunderstanding, and lack of professional education have prevented accurate treatment information from reaching most clinicians and patients. These obstacles also have slowed empirical efforts to improve treatment outcomes for people with DID. Emerging neurobiological findings in DID provide essential information that can be used to improve treatment outcomes. AREAS COVERED: In this narrative review, the authors discuss symptom characteristics of DID, including dissociative self-states. Current treatment approaches are described, focusing on empirically supported psychotherapeutic interventions for DID and pharmacological agents targeting dissociative symptoms in other conditions. Neurobiological correlates of DID are reviewed, including recent research aimed at identifying a neural signature of DID. EXPERT OPINION: Now is the time to move beyond historical controversy and focus on improving DID treatment availability and efficacy. Neurobiological findings could optimize treatment by reducing shame, aiding assessment, providing novel interventional brain targets and guiding novel pharmacologic and psychotherapeutic interventions. The inclusion of those with lived experience in the design, planning and interpretation of research investigations is another powerful way to improve health outcomes for those with DID.

Psycho-Neurobiology and Its Potential Influence on Psychotherapy: Being, Doing, and the Risk of Scientism.

Neuroscientific information may transform the modern practice of psychotherapy. Still we must pay heed to the most salient of the common factors generating therapeutic change: the relationship between patient and therapist. Likewise, brain and body are both part of mind and we ignore this at our clinical peril. Research on affective, cognitive, mnemic, somatic, psychophysiologic, developmental, and integrative mental processes, amongst others, must hold to a high standard of translation from basic scientific findings or we risk practicing a psychotherapy enslaved to an authoritarian scientism as a substitute for the creation of unfettered intimacy and engagement. A balanced approach is required if in trauma treatment, for example, we are to be both potential beneficiaries of understanding what is in our human heads while not losing track of our very human hearts. Each clinician need develop a basic knowledge of neuroscience in order to critically assess the meanings of new findings and their proper place in the practice of all the psychotherapies.

Issues in consultation for treatments with distressed activated abuser/protector self-states in dissociative identity disorder.

The identified "problem self-state" in a dissociative disorder consultation is like the identified patient in a family therapy; the one who is identified may have an assigned role to be blamed which serves the function of deflecting the activities of painful self-states in other family members. In consultation, the "family" includes the therapist in addition to the patient. When the state identified as a problem self-state is an abuser/protector self-state, complications often involve the profound nature of transference-countertransference enactments between patient and therapist, the delusion of separateness, chronic and acute threats of suicide, negative therapeutic reactions, and the evocation of intense negativity. They also involve affect phobia in both patient and therapist, and the emergence of intense shame in the clinical dyad amongst additional potential burdens in these complicated treatments. The task of the consultant is to protect both patient and therapist from an untoward outcome while relieving the painful burdens entailed by the treatment. The typical core dynamic of the abuser/protector state is as a repository for shame/humiliation welded to anger/rage. This dynamic, and others, must be understood in order to resolve these impasses and create useful movement toward growth in both patient and therapist.

The paradox of "detachment disorders": binding-disruptions of dissociative process.

This case is discussed in the contexts of affect theory, attachment theory, and dissociative experience. Dissociative adaptations to living that become entrenched resistances during psychotherapeutic inquiry give way to a scrupulous attention to the characteristics of dissociative experiencing. Somatosensory free association and appreciation of experiential aspects of depersonalization, derealization, and dissociative amnesia open new areas of negotiation between patient and therapist. Paradigms from infant attachment and adult attachment research parsimoniously explicate psychodynamic formulations. "Conflicted interest" and "conflicted disinterest" are proposed to flesh out appreciation of the child's inner experience during Type A and Type C attachment experiences. The Type D attachment style is consistent with a dissociative phenotype. The concept of "isolated subjectivity" can help explain the extent to which individuals both know and don't know about their experience, in the same moment, and without conscious conflict or anxiety.